Nicktoons: Attack of the Toybots is the 2007 sequel to the 2005 Nicktoons Unite and 2006 Nicktoons: Battle for Volcano Island. Characters from SpongeBob SquarePants, Danny Phantom, The Fairly Oddparents, The Adventures of Jimmy Neutron: Boy Genius, Tak and the Power of Juju, My Life as a Teenage Robot, Invader Zim, Ren & Stimpy, and Rocko's Modern Life will appear. Also in the Nintendo DS version, characters for El Tigre: The Adventures of Manny Rivera and Catscratch appear too.

Professor Calamitous attempts to be declared the biggest genius in a reality game show, he creates an army of robots that are twisted homages to the Nicktoons (And regular toys) called the "Toybots", And launches them on a multi-dimensional invasion. Now the gang must defeat the "Toybots" and foil the Professor’s plan.