Igor, the movie, follows a hunchbacked lab assistant named Igor (voiced by John Cusack) forced to serve a mad scientist while dreaming of one day becoming a notorious mad scientist himself and winning the Evil Science Fair. Other stars contributing their voice talents to the film are Molly Shannon (as Eva), Steve Buscemi (as Scamper), Sean Hayes (as Brain) and Eddie Izzard (as the maniacal Dr. Schadenfreude).

In the Wii and PC versions of the game, players have the ability to choose one of the main characters (Igor, Eva, Scamper or Brain) and play either simultaneously or cooperatively with up to four people. They’ll be challenged to play within locales from the film, fight enemies and achieve goals that advance them through the storyline.

The Nintendo DS version utilizes the stylus to perform movement combinations, combat enemies and solve puzzles. Players can custom build their own monsters to take on puzzle challenges and battle against other mad scientists.