Approximately 20 years after the events depicted in Deus Ex, the world is only beginning to recover from a catastrophic worldwide depression brought on by technology run amok and a secret conspiratorial war.

The winner-take-all geopolitics of mid-21st century Earth have given way to a struggle over more basic concerns: food, water, reestablishing civil law and cleaning up biological and nano-tech fallout. In this chaotic recovery, several religious and political factions see an opportunity to re-shape a worldwide government to their agendas, understanding that the right moves now could determine the shape of human society for decades - even centuries - to come.

Amidst the debris, the player Alex D. emerges in searching the identities of true players behind the power struggles and the source of his own mysterious origins. In a techno-nightmare of the fragile revival or ultimate decimation of human civilization, take part in a dark dramatic struggle to raise the world from its own ashes.